

The story starts at the funeral of Ace, one of the Desert Rangers featured in the original game. Controlling a squad of newly recruited rangers, the player is tasked with finding out who killed Ace and why they did it, and try to complete Ace's original mission. General Vargas, just a few days prior, sent Ace out to investigate a strange radio signal that speaks of "man and machine becoming one" while threatening to attack and wipe out the Desert Rangers. This greatly troubles General Vargas, the leader of the Desert Rangers. The experienced ranger Ace is found dead by locals with signs of violence on his body. The game begins in 2102, fifteen years after the events of the original Wasteland, with the Rangers now occupying the former Guardian Citadel, which had formerly housed deranged technology-worshipping monks (the Guardians), but is now fully under Ranger control after the monks had been wiped out by the Rangers. Years later, together they formed "the Desert Rangers, in the great tradition of the Texas and Arizona Rangers", to help other survivors in the desert and beyond it. The soldiers sought shelter in the prison, expelled the inmates, and invited nearby survivalists to join them shortly thereafter. Army Engineers were in the desolate southwestern desert constructing bridges in an area with a number of small survivalist communities and a newly constructed federal death row prison with light industrial facilities. On the day of the cataclysm, a company of U.S. The game is set in an alternate history timeline, in which a nuclear war between the United States and Soviet Union took place in 1998 in relation to an impact event involving a cluster of meteors that sparked a global nuclear war. The non-player characters in the party each have their own personality, motivations, opinions, and agendas. The player characters are highly customizable and the player's choice of statistics, skills, and appearance gives them an individualized personality.

The player's party has room for seven characters, including the four player-designed characters and up to three non-player characters (NPCs). It is a turn-based and party-based role-playing game with tactical combat. Wasteland 2 features a semi-overhead view with a rotatable camera.
